A primate model for hearing research using non-human primate common marmoset

2015 Fiscal Year Final Research Report

• Project/Area Number: 24592560
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Keio University
• Principal Investigator: Fujioka Masato 慶應義塾大学, 医学部, 助教 (70398626)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: トランスレーショナルリサーチ / 感音難聴 / 聴覚障害 / 霊長類モデル / コモンマーモセット

Outline of Final Research Achievements

Model animals are indispensable for the success in translational research but there are always species differences in between rodent models, commonly used for ENT/audiology research to achieve non-clinical proof of concept studies, and human cases. Notably, this discrepancy may often lead to failures in the drug development. In the study, we are trying to establish a primate deafness model using a small non-human primate common marmoset to mind the species gap. We revealed a local anatomy of temporal bone, surgical roots for the drug discovery to the inner ear via semicircular canal and round window niche, basic information in its audiology. We prepared for the ABR and OAE recording, animal facility and OR for marmosets. We are going to achieve a noise-induced hearing loss model in the species near future.

Free Research Field

耳科学・聴覚医学