High-Efficiency Differentiation of Auditory Neurons from Bone Marrow Mesenchymal Stem Cells Aiming at Regenerative Therapy of Auditory Nerve.

2015 Fiscal Year Final Research Report

• Project/Area Number: 24592567
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Health Sciences University of Hokkaido (2014-2015); Fujita Health University (2012-2013)
• Principal Investigator: Shimomura Atsushi 北海道医療大学, リハビリテーション科学部, 教授 (50340237)
• Co-Investigator(Kenkyū-buntansha): KOGO AKIKO 群馬大学, 大学院医学系研究科, 講師 (20340242) ; NOMURA RYUJI 藤田保健衛生大学, 医学部, 講師 (20325161)
• Co-Investigator(Renkei-kenkyūsha): TAKUMI YUTAKA 信州大学, 学術研究院医学系, 准教授 (70312501)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 骨髄由来間葉系幹細胞 / グルタミン酸作動性ニューロン / 感音難聴 / 聴神経 / 再生治療 / エピジェネティック

Outline of Final Research Achievements

The aim of our study is to develop the technique for high-efficiency differentiation of auditory neurons from bone marrow mesenchymal stem cells (BMSC). The transcription factor Tlx3 and Pax2 is essential for auditory neural development. Here, we found that Tlx3 and Pax2 regulate auditory neural differentiation through their interaction with epigenetic enzymes. Our results suggest that reagents that can affect the activity of these enzymes might be useful for high-efficiency differentiation of auditory neurons from BMSC.

Free Research Field

再生医療