2014 Fiscal Year Final Research Report
Leukotriene E4 receptor in human nasal mucosa-the expression and the roles of P2Y12 receptor
| Project/Area Number |
24592576
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | ロイコトリエンE4 / P2Y12 / GPR99 / 鼻粘膜 / 鼻アレルギー / ムチン |
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| Outline of Final Research Achievements |
The cysteinyl leukotrienes (CysLTs) are lipid mediators that have been implicated in the pathogenesis of allergic rhinitis. CysLT1 receptor is sensitive to the CysLT1 receptor antagonist currently used to treat asthma and allergic rhinitis. Recent studies have begun to uncover receptors selective for LTE4:P2Y12.To clarify the expression of P2Y12 receptor in human nasal mucosa, we investigated immunohistochemical localization of P2Y12 receptor in human nasal mucosa, and mucus secretion by LTE4 in vitro. The immunohistochemical study revealed that epithelial cells, submucosal glands and vascular endothelial cells showed intense immunoreactivity for P2Y12 receptor.LTE4 significantly induced the release of MUC5AC mucin from airway epithelial cells.A P2Y12 receptor antagonist, partially inhibited the LTE4-induced release of MUC5AC protein in the airway.These results suggest that LTE4 may play some important roles in allergic mucus secretion partially via activation of P2Y12 receptor.
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| Free Research Field |
鼻アレルギー
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