Research on mechanism of relation between nasal allergy and sleep disorders with discovering new treatment.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592578
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Nagoya City University
• Principal Investigator: NAKAYAMA Meihou 名古屋市立大学, 医学(系)研究科(研究院), 准教授 (30278337)
• Co-Investigator(Kenkyū-buntansha): HIDA Hideki 名古屋市立大学, 大学院医学研究科, 准教授 (00305525) ; SUZUKI Motohiko 名古屋市立大学, 大学院医学研究科, 准教授 (50326138) ; KURIYAMA Shinichi 名古屋市立大学, 大学院医学研究科, 臨床研究医 (10625560)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: アレルギー性鼻炎 / 不眠症 / 海馬

Outline of Final Research Achievements

Our gorals are, creating nasal allergic mice, observing neuron cells damage of hippocampus by argyophil III stain, and measuring sleep brain wave to compare how do nasal allergy mice affect their hippocampus, and their sleep quality. After the first step, new anti-allergic medicine CD40 created by Motohiko Suzuki will inject to all mice, to observe if the medication may improve their allergy as well as their sleep quality, also assist neuron cells function in hippocampus. At this moment, several experiment regarding effectiveness on CD40 to mice nasal allergy already done by our teams. In our future works, once this subject is completed, this CD40 may be possible using to human to help how are suffered with nasal allergy and sleep disorders. Since insomnia has been reported that may affect human memory, this project may also help neuron cells in brain.

Free Research Field

睡眠医療