Gene mutation and 3D-conformation of proteins related to EGFR pathway in head and neck cancer

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592587
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Hokkaido University
• Principal Investigator: HOMMA Akihiro 北海道大学, 医学(系)研究科(研究院), 准教授 (30312359)
• Co-Investigator(Kenkyū-buntansha): HATAKEYMA Hiromitsu 北海道大学, 北海道大学病院, 助教 (10455652)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 頭頸部癌 / gene mutation / EGFR pathway

Outline of Final Research Achievements

DNA, mRNA and protein materials were extracted from normal mucosa and tissue of head and neck squamous cell carcinoma obtained from surgical specimen or biopsied tissue. 3D-conformation of the proteins interactions between drugs and other proteins were analyzed by amino-acid residue sequence and by atomic-level structure.
HB-EGF, a ligand of epidermal growth factor receptor (EGFR), has contained more in the cetuximab-sensitive head and cancer cell line than in the cetuximab-resistant cell line. The increase of HB-EGF activated the EGFR pathway and reduced the efficacy of cetuximab.

Free Research Field

頭頸部癌