2014 Fiscal Year Final Research Report
Molecular genetic diagnosis of head and neck tumor
| Project/Area Number |
24592593
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 頭頸部腫瘍 / 遺伝子 / 分子遺伝学 / 遺伝子発現 |
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| Outline of Final Research Achievements |
In this study, we tried to developed molecular genetic diagnosis systems of head and neck tumor. We extracted mRNA from 20 head and neck tumore patients with 5 different types. By using the cDNA microarray analysis to investigate the gene expression patterns to clustered each cell type of tumor.
As a results, we can clearly showed the molecular characteristics of head and neck tumors (Adenoid cystic carcinoma, Mucoepidermoid carcinoma, Acinic cell carcinoma, Salivary duct carcinoma, Adenocarcinoma, not otherwise specified) by using clustering analysis on the basis of gene expression patterns.
We also developed the molecular diagnostic system for quit small samples obtained from fine needle biopsy. In our system, we can also separate all 5 cell type of head and neck tumor based on the gene expression profiles of 22 selected genes.
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| Free Research Field |
耳鼻咽喉科学
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