2014 Fiscal Year Final Research Report
Development of less-intensive treatment for HPV-associated head and neck cancer.
Project/Area Number |
24592597
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Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Otorhinolaryngology
|
Research Institution | Kagawa University |
Principal Investigator |
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Keywords | papillpmavirus / head and neck / p16 / prognosis / radiosensitivity / drugsensitivity |
Outline of Final Research Achievements |
It is known that the incidence of head and neck squamous cell carcinoma (HNSCC) associated with papillomavirus (HPV) infection has increased over the past decades. Evidence from retrospective case series suggests improved prognosis in patients with HPV-positive HNSCC, thus the development of less-intensive treatment is expected. Although overall survival in patients with HPV-positive was better than that with HPV-negative tumors, no significant difference was observed. In this study, we could not show the difference of sensitivity to radiation and anti-cancer drug according to HPV status using collagen gel droplet embedded culture drug sensitivity test (CD-DST).
|
Free Research Field |
外科系臨床医学・耳鼻咽喉科学
|