2014 Fiscal Year Final Research Report
Modulation of satellite cells activity and MyoD in rat thyroarytenoid muscle after reinnervation
| Project/Area Number |
24592603
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kumamoto University |
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Principal Investigator |
YOSHIHIKO Kumai 熊本大学, 大学院生命科学研究部, 助教 (00555774)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | satellite cell |
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| Outline of Final Research Achievements |
The expression levels of mRNAs encoding M-cadherin and MyoD in the TA muscle of the DNV group were significantly higher (p<0.01) than in the control throughout the study period. These mRNA levels in the ANS group were significantly higher (p<0.01) at ≦ 1week than in the controls, but fell to control levels at ≧ 3weeks. In the ANS group, recovery of muscle area and NMJ structure occurred by 3 weeks.
These data suggested that NMJ formation following reinnervation might prompt recovery of M-cadherin and MyoD mRNA expression to the quiescent level of SCs.
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| Free Research Field |
Laryngology
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