regeneration of tracheal cartilage using chondrocytes and perichondrial cells

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592604
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Fukushima Medical University
• Principal Investigator: NOMOTO Yukio 福島県立医科大学, 医学部, 講師 (70508811)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 気管軟骨 / 再生 / 軟骨膜細胞 / 軟骨細胞

Outline of Final Research Achievements

The artificial prosthesis that our group successfully used clinically for tracheal regeneration has not been implanted to pediatric cases because of its polypropylene frame. The ultimate goal of our study is to regenerate cartilaginous frame of trachea. In this study, we developed a novel bioengineered prosthesis with chondrocytes and perichondrial cells for regeneration of trachea, and examined its effectiveness by implantation. Regenerated cartilage was observed in the tracheal defect of rabbit that had been reconstructed by the novel bioengineered prosthesis. The result indicated that the bioengineered trachea with chondrocytes and perichondrial cells have potential for regeneration of tracheal cartilage.

Free Research Field

耳鼻咽喉科