2014 Fiscal Year Final Research Report
Pathological mechanism and a new method for the treatment of retinal vein occlusion using sugar-chain modified liposome.
| Project/Area Number |
24592623
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHJI Masahito 滋賀医科大学, 医学部, 教授 (90252650)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | タンパク質 / 細胞・組織 / 応用動物 / 脂質 |
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| Outline of Final Research Achievements |
Liposome is one of the most effective tools for drug delivery systems. Liposome offers improved pharmacokinetic properties, controlled and sustained release of drugs. liposomes encapsulated with human immunoglobulin for intravitreal administration were prepared and characterized. The liposomes were prepared using the improved cholate dialysis method. The intensity-average diameter of the liposomal nanoparticles was approximately 100 nm. Encapsulation efficiency was approximately 16-21%. The size distribution of liposomes remained stable until 45 days. The efficiency of leakage at 60 days was approximately 35 %. The leakage concentration of human immunoglobulin was gradually increased during the study period. The liposomes can lead to the slow and controlled release of drug in the vitreous. These results suggest that liposomes encapsulated with immunoglobulin for intravitreal administration may be feasible for antibody treatment of ocular diseases.
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| Free Research Field |
眼科学
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