Elucidation of mechanisms for choroidal neovascularization in high myopia

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592624
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kyoto University
• Principal Investigator: YAMASHIRO Kenji 京都大学, 医学(系)研究科(研究院), 講師 (80399617)
• Co-Investigator(Kenkyū-buntansha): MURAKAMI Tomoaki 京都大学, 大学院医学研究科眼科学, 助教 (50549095)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 強度近視 / WNT7B / 脈絡膜新生血管

Outline of Final Research Achievements

Recently, the prevalence of myopia is rapidly increasing especially in Asian countries. High myopia can lead to severe visual disturbance due to its complications such as choroidal neovascularization. By performing genome-wide association studies and animal studies, we found that WNT7B, C1orf110, and MMP20 might have important roles in the development of choroidal neovascularization in high myopia.

Free Research Field

眼科学