2014 Fiscal Year Final Research Report
Inhibition of RPE senescence by AMPK activation
| Project/Area Number |
24592630
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOSAKA Jun 国際医療福祉大学, 基礎医学研究センター, 教授 (40243216)
YONEZAWA Tomoko 岡山大学, 医歯(薬)学総合研究科, 助教 (30304299)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 加齢黄斑変性 |
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| Outline of Final Research Achievements |
Retinal pigment epithelial cells (RPE) has a variety of physiological functions to maintain homeostasis of the retina. In the age-related macular degeneration, homeostasis of the retina collapses by decreased function of the RPE associated with aging, and leads to visual disturbance. In this study, for the ARPE-19 and human iPS-derived RPE, we induced senescence of RPE by chronic oxidative stress, and revealed a change in the functions of the RPE associated with aging. In addition, using models of inflammation to induce epithelial-mesenchymal transition in the RPE, we revealed that the activation of AMPK inhibits epithelial-mesenchymal transformation in the RPE.
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| Free Research Field |
医歯薬学
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