Regeneration of retinal vasculature in diabetic retinopathy with growth factors and signal transduction

2015 Fiscal Year Final Research Report

• Project/Area Number: 24592631
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Nagasaki University
• Principal Investigator: SUZUMA Kiyoshi 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (80335265)
• Co-Investigator(Kenkyū-buntansha): TSUIKI Eiko 長崎大学, 医歯薬学総合研究科(医学系), 講師 (30363493) ; FUJIKAWA Azusa 長崎大学, 病院(医学系), 講師 (60363503) ; MATSUMOTO Makiko 長崎大学, 医歯薬学総合研究科(医学系), 助教 (70437903) ; KITAOKA Takashi 長崎大学, 医歯薬学総合研究科(医学系), 教授 (80234235)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: VEGF / 糖尿病網膜症 / エリスロポエチン / コハク酸

Outline of Final Research Achievements

Diabetic retinopathy is the leading cause of new onset blindness among working age individuals. Vascular endothelial growth factor (VEGF) has been strongly implicated as a primary mediator of ocular complications in diabetes and age-related macular degeneration. We reported that mechanical stretch induced expression of VEGF and its receptors in retinal vascular cells and demonstrated that retinal expression of VEGF and VEGF-R2 was increased during hypertension in vivo. It has recently been demonstrated that G protein-coupled receptor 91 (GPR91: a succinate receptor) plays a major role in both vasculature development and retinal angiogenesis. Recently, we have reported increases of succinate in vitreous from proliferative diabetic retinopathy patients and the signaling pathways involved in hypertension-dependent succinate release.

Free Research Field

眼科学