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2015 Fiscal Year Final Research Report

Regeneration of retinal vasculature in diabetic retinopathy with growth factors and signal transduction

Research Project

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Project/Area Number 24592631
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionNagasaki University

Principal Investigator

SUZUMA Kiyoshi  長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (80335265)

Co-Investigator(Kenkyū-buntansha) TSUIKI Eiko  長崎大学, 医歯薬学総合研究科(医学系), 講師 (30363493)
FUJIKAWA Azusa  長崎大学, 病院(医学系), 講師 (60363503)
MATSUMOTO Makiko  長崎大学, 医歯薬学総合研究科(医学系), 助教 (70437903)
KITAOKA Takashi  長崎大学, 医歯薬学総合研究科(医学系), 教授 (80234235)
Project Period (FY) 2012-04-01 – 2016-03-31
KeywordsVEGF / 糖尿病網膜症 / エリスロポエチン / コハク酸
Outline of Final Research Achievements

Diabetic retinopathy is the leading cause of new onset blindness among working age individuals. Vascular endothelial growth factor (VEGF) has been strongly implicated as a primary mediator of ocular complications in diabetes and age-related macular degeneration. We reported that mechanical stretch induced expression of VEGF and its receptors in retinal vascular cells and demonstrated that retinal expression of VEGF and VEGF-R2 was increased during hypertension in vivo. It has recently been demonstrated that G protein-coupled receptor 91 (GPR91: a succinate receptor) plays a major role in both vasculature development and retinal angiogenesis. Recently, we have reported increases of succinate in vitreous from proliferative diabetic retinopathy patients and the signaling pathways involved in hypertension-dependent succinate release.

Free Research Field

眼科学

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Published: 2017-05-10  

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