Evaluation of the ocular surface mucin functions; Barrier and wettability on the ocular surface

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592657
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Toho University
• Principal Investigator: HORI Yuichi 東邦大学, 医学部, 教授 (70379171)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 眼表面ムチン / ドライアイ / バリア機能 / 水濡れ性

Outline of Final Research Achievements

Mucins, which are one of the major component on the ocular surface, play very important roles, such as barrier function and ocular wettability. Recently, two new eye drops have been introduced in Japan to treat dry eye. In this study, we investigated the pharmacologic action of these agents in terms of the production of the mucins and water. We also established the modified contact angle measuring system to evaluate the relationship between mucin and wettability on the ocular surface. We believe that our results can contribute to figure out the mechanism of the dry eye, and to establish the more effective treatment for the patients with dry eye.

Free Research Field

眼科学