Characterization of mouse models for age-related macular degeneration

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592664
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: 独立行政法人国立病院機構(東京医療センター臨床研究センター)
• Principal Investigator: NAKAYAMA MAO 独立行政法人国立病院機構(東京医療センター臨床研究センター), 分子細胞生物学研究部, 研究員 (20624810)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 加齢黄斑変性 / 感受性遺伝子 / HTRA1 / ARMS2 / トランスジェニックマウス / 喫煙

Outline of Final Research Achievements

Genetic and environmental factors are believed to be involved in the onset of age-related macular degeneration (AMD).We generated three mouse lines that overexpressed mouse HtrA1, human ARMS2 and ARMS2(A69S) throughout the entire mouse body. CNV similar to human AMD was observed progression in HtrA1 Tg mouse at 12-month-old. Exposure to mainstream cigarette smoke enhanced the CNV rate in HtrA1 Tg mouse. Our data suggested that HtrA1 overexpression alone is a strong risk factor for wet AMD, which is the predominant form of AMD in the Japanese population.

Free Research Field

眼分子生物学