Three dimensional vascular images of choroidal disease

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592682
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Tokyo Medical University
• Principal Investigator: MIURA Masahiro 東京医科大学, 医学部, 准教授 (60199958)
• Co-Investigator(Renkei-kenkyūsha): YASUNO Yoshiaki 筑波大学, 数理物質科学研究科, 講師 (10344871)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 網脈絡膜疾患 / ドップラー計測 / 光干渉断層計 / 血管 / 3次元画像

Outline of Final Research Achievements

Using Doppler optical coherence tomography(OCT), we can quantitatively evaluate the human blood flow volume in choroid and retina, and human three-dimensional (3-D) chorioretinal vascular architecture, in vivo. 1) Doppler OCT with plethysmography provided an accurate quantitative assessment of the absolute blood flow volume in choroidal vessels. 2) We preliminary evaluated 3-D vascular structure of various exudative macular disease using Doppler OCT. 3) We evaluated the 3-D architectureof neovascularization in proliferative diabetic retinopathy using Doppler OCT. 4) The therapeutic effect after three consecutive intravitreal aflibercept injections for polypoidal choroidal neovascularization was evaluated using Doppler OCT. Doppler OCT imaging is noninvasive, has a short measurement time, and may potentially function as a noninvasive alternative to FA and ICGA for the assessment of various chorioretinal vascular diseases.

Free Research Field

眼科学