Molecular Analysis of CEACAM Family in Hepatoblastoma

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592693
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatric surgery
• Research Institution: Niigata University
• Principal Investigator: NAKAYA KENGO 新潟大学, 医歯学系, 助教 (20625173)
• Co-Investigator(Kenkyū-buntansha): WAKAI Toshifumi 新潟大学, 医歯学系, 教授 (50372470) ; KUBOTA Masayuki 新潟大学, 医歯学系, 教授 (50205150)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 肝芽腫 / CEACAM / 接着因子

Outline of Final Research Achievements

Hepatoblastoma is an uncommon malignant liver cancer occurring in infants and children. Currently the survival rate of hepatoblastoma has been better improved, but the prognosis is still poor when the disease is unresectable. In this study, we addressed whether carcinoembryonic antigen-related cell adhesion molecule (CEACAM), a type of adhesion molecule involved in cancer progression, has any impact on the prognosis of hepatoblastoma. The results of our immunohistochemical analysis showed that the cases with increased levels of CEACAM6 expression relatively exhibited advanced tumor stage with lung metastasis. Based on these obtained results, CEACAM6 might play a role on cancer metastasis in hepatoblastoma.

Free Research Field

小児外科学