Improvement of ischemia reperfusion injury after liver transplantation by introduction of MSCs

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592694
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatric surgery
• Research Institution: Kyoto University
• Principal Investigator: OKAMOTO Shinya 京都大学, 医学(系)研究科(研究院), 研究員 (00329377)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: MSCs / exozome / 肝移植 / 部分肝移植

Outline of Final Research Achievements

We have shown that mesenchymal stem cells administered via portal vein is effective in terms of amelioration of ischemia-reperfusion injury. We also established the technique with which we can extract exosome from supernatant of culture media of MSCs. Exosome from MSCs was shown to have immuno-moduratory effect and suppress immunological reaction between allogeneic cells. In order to evaluate the effect of exosome we esbalished rat liver transplantation model. The tentative results showed that the exosome have a potential to improve rat survival after partial liver transplantation.

Free Research Field

小児外科、移植外科