Eosinophilic inflammation associated with congenital gastrointestinal obstructive anomalies

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592702
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatric surgery
• Research Institution: Gunma Institute of Public Health and Environmental Sciences
• Principal Investigator: YAMADA Yoshiyuki 群馬県衛生環境研究所, 研究企画係, 研究員 (80309252)
• Co-Investigator(Kenkyū-buntansha): IKEDA Hitoshi 獨協医科大学, 医学部, 教授 (10326928) ; TAGUCHI Tomoaki 九州大学, 医学(系)研究科(研究院), 教授 (20197247) ; HAYASHI Yasuhide 群馬県環境衛生研究所, 研究企画係, 研究員 (30238133) ; KATO Masahiko 東海大学, 医学部, 准教授 (30292593) ; HIRATO Junko 群馬大学, 医学部附属病院, 准教授 (60208832) ; KUROIWA Minoru 東邦大学, 医学部, 教授 (90234583)
• Research Collaborator: MATSUMOTO Kenji ; NISHI Akira ; SUZUKI Norio
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 先天性消化器疾病学 / 好酸球

Outline of Final Research Achievements

This study aimed to determine the relationship between eosinophilic gastrointestinal disorders (EGID) and congenital gastrointestinal (GI) obstructive anomalies such as Hirschsprung disease and congenital esophageal atresia and stenosis. Some patients with congenital GI obstructive anomalies had eosinophil-dominant infiltration in the GI tract. We analyzed these patients’ clinical findings and laboratory data and reported their characteristics. In addition, this study contributed to the development of methods to evaluate the inflammation and pathogenesis of EGID. In addition, a novel dietary treatment of eosinophilic gastroenteritis, the multiple-food elimination diet, was shown to be effective in these patients.

Free Research Field

小児科学、アレルギー免疫学