2014 Fiscal Year Final Research Report
Evidence of epithelial-mesenchymal transition in skin wound healing
| Project/Area Number |
24592718
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUNAGA Ataru 自治医科大学, 形成外科, 助教 (00406117)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 創傷治癒 |
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| Outline of Final Research Achievements |
We established Tie2Cre;Ai14;COL-EGFP mice in which Tie2-expressing cells were genetically marked with tdTomato and collagen type1-expressing cells expressed EGFP. Using the transgenic mice, we made hypertrophic scar models and normal scar models, and analyzed the scars with immunofluorescent imaging.
In the normal scars, tdTomato-positive cells (tdT-cells) did not express EGFP, suggesting tdT-cells did not produce collagen type 1. In the other hand, tdT-cells in the hypertrophic scars partially expressed EGFP, suggesting tdT-cells contributed to dermal fibrosis.
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| Free Research Field |
創傷治癒
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