A polymorphysm in the IL-6 promotor region associated with the keloid in the Japanease population

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592723
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Plastic surgery
• Research Institution: Nippon Medical School
• Principal Investigator: MAMIKO Tosa 日本医科大学, 医学部, 講師 (30301568)
• Co-Investigator(Kenkyū-buntansha): WATANABE Atsushi 日本医科大学, 医学部, 准教授 (10307952) ; GHAZIZADEH M 日本医科大学, 付置研究所, 准教授 (30190979)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ケロイド / ＩＬ－６ / ＳＮＰ / 遺伝子解析

Outline of Final Research Achievements

Keloid develops as an abnormal wound healing lesion in genetically predisposed individuals.IL-6 is involved in both cell proliferation and collagen synthesis. We previously reported up-regulation of the IL-6 and its involvement in the pathogenesis of keloid. In this study, we investigated whether SNPs in the IL-6 promoter region or IL-6 receptor (IL-6R) gene might be associated with keloid and if so its relationship with clinical severity of the disease.
The IL-6 -572G/C polymorphism was significantly associated with keloid in general and clinical severity of keloid in particular, thus suggesting a potential role for the IL-6 promoter SNP analysis in predicting the susceptibility to keloid formation and facilitating therapeutic managements.

Free Research Field

ケロイド