Examination of a different membranes on cytokine adsorption on circulating cytokine and search of a biomarker as a prognosticator in a sepsis rat continuous heamodiafiltration model

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592732
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: University of Yamanashi
• Principal Investigator: HARII Norikazu 山梨大学, 総合研究部, 准教授 (80377522)
• Co-Investigator(Kenkyū-buntansha): MATSUDA Kenichi 山梨大学, 総合研究部, 教授 (60282480) ; GOTO Junko 山梨大学, 総合研究部, 助教 (60530102) ; YANAGISAWA Masahiko 山梨大学, 総合研究部, 助教 (90597022)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 血液浄化療法 / 敗血症性多臓器不全 / ラットエンドトキシンショックモデル

Outline of Final Research Achievements

Sepsis is a systemic inflammatory response syndrome caused by several infections. Excessive production of inflammatory mediators like cytokines and chemokines may develop multiple organ failure leading to death. Although hemodiafiltration is used as a renal replacement therapy, it is often considered for the treatment of septic renal failure with the concept of modulating immune response and ameliorating failure of other organs. Various membranes for hemodiafiltraion are commercialized and in each having their peculiar removal characteristics of the substance in blood. It is still unclear which membrane is suitable for the treatment of severe sepsis. We have been established hemodiafiltraion system for entdotoxin shock rat. We have studied the adsorption of influencing circulating levels of inflammatory mediators like cytokines for comparing several membranes and identified the polyarylate/polyethylsulfon(PEPA) membrane efficiently adsorbed the serum interleukin-6.

Free Research Field

集中治療医学