Exploratory research for the better outcome of septic encephalopathy

2016 Fiscal Year Final Research Report

• Project/Area Number: 24592734
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Institute of Physical and Chemical Research (2015-2016); Kyoto University (2012-2014)
• Principal Investigator: Imamura Yukio 国立研究開発法人理化学研究所, 生命システム研究センター, 研究員 (90447954)
• Research Collaborator: YOSHIKAWA nao 京都大学, 医学研究科・人間健康科学専攻, 大学院生 ; WANG huan 京都大学, 医学研究科・分子医学系専攻, 大学院生
• Project Period (FY): 2012-04-01 – 2017-03-31
• Keywords: 敗血症性脳症

Outline of Final Research Achievements

In this study, we examined molecular mechanisms and challenged to find a novel way of medical intervention for septic encephalopathy. To tackle these issues, we conducted the following experiments: 1) establishment and evaluation of mouse model for septic encephalopathy, 2) possible involvement of glutamatergic synaptic receptor and interleukin-1 receptor for the molecular mechanisms, 3) tested whether activation of anti-inflammatory pathways improved septic encephalopathy. Our findings suggest that histone acetylation mediated regulation of ionotropic and interleukin receptors for the better outcome of septic encephalopathy. In addition, activation of anti-inflammatory pathway may be beneficial for the better prognosis of septic encephalopathy

Free Research Field

救急医学