Development of non-invasive method to quantitatively measure brain perfusion and metabolism in carbon monoxide poisoning

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592746
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Iwate Medical University
• Principal Investigator: FUJIWARA Shunro 岩手医科大学, 医学部, 助教 (60405842)
• Co-Investigator(Kenkyū-buntansha): BEPPU Takaaki 岩手医科大学, 医学部, 教授 (70275543)
• Co-Investigator(Renkei-kenkyūsha): OGASAWARA Kuniaki 岩手医科大学, 医学部, 教授 (00305989)
• Research Collaborator: LE BIHAN Denis フランス原子力庁超高磁場, MRI 研究センターNeurospin ; LUISA Ciobanu フランス原子力庁超高磁場, MRI 研究センターNeurospin ; DJEMAI Boucif フランス原子力庁超高磁場, MRI 研究センターNeurospin
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 医学 / 脳科学 / 脳計測科学 / MRI / 画像解析 / 統計学 / 放射線科学

Outline of Final Research Achievements

In this study, 1H-magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) were performed at 3-Tesla Magnetic Resonance Imaging system for estimating brain temperature (BT) and the extent of white matter damage in carbon monoxide (CO) poisoned patients and healthy control subjects.
Finally, we got the following results: 1.BT of CO-poisoned patient was significantly higher in the acute phase than that of the control. In the subacute phase, BT was significantly lower than that in the acute phase but was kept higher than the controls. 2.BT in the subacute CO-poisoned patient correlated with the extent of white matter damage. 3.New DTI-based BT was significantly correlated with MRS-based BT which can accurately estimate BT. Consequently, this results suggest that we achieved the purpose to non-invasively measure brain perfusion and metabolism and to predict development of symptom in a part of the patients although it needs more number of subjects to exactly validate.

Free Research Field

MRIを用いた非侵襲的な脳機能計測および脳循環代謝計測