2015 Fiscal Year Final Research Report
Anticipation of organ dysfunction by immmunological monitoring in severe trauma and burns
| Project/Area Number |
24592748
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 免疫 / 侵襲 / 臓器不全 / 白血球 / フェノタイプ解析 |
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| Outline of Final Research Achievements |
Sepsis-induced organ dysfunction (SIOD) has been considered to be involved in leukocyte phenotypic changes in severely injured and burned patients. Our question is whether SIOD can be predicted by leukocyte immunophenotyping or not in these trauma or burned patients, using a new array method we developed. Among 16 patients with trauma/burns and 5 healthy volunteers, we analyzed the leukocyte phenotypes including CD4/8/11c/16b/25/36/66b/123/127/161, Toll like receptor (TLR)-2/4, CC-Chemokine receptor (CCR)-2/4/5, CXC-Chemokine receptor (CXCR)-3, and CRTh2. In burned patients, phenotypes were lower not only in CCR5 and CXCR3 than those in both trauma and healthy subjects, and also in CD68 and CD123 than those in trauma, whereas phenotypes in Th1 (CCR5, CXCR3) and monocytes /dendritic cells (CCR2, CD11c) were increased. Based on these results, re-increase of Th1 phenotypes may predict infectious complications or organ dysfunction after burn insults.
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| Free Research Field |
救急医学
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