2014 Fiscal Year Final Research Report
Immunocytochemical characterization of type B synoviocyte in the rat temporomandibular joint: Its possible participation in synovial vascularization
| Project/Area Number |
24592760
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Morphological basic dentistry
|
|---|
| Research Institution | Niigata University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MAEDA Takeyasu 新潟大学, 医歯学系, 教授 (40183941)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 顎関節 / 滑膜 / 滑膜表層細胞 / 血管 |
|---|
| Outline of Final Research Achievements |
The synovial lining layer in the temporomandibular joint (TMJ) contains two types of synovial lining cells (SLC): a macrophage-like type A cell and fibroblast-like type B cell. The present study investigated the immunocytochemical characteristics of the SLC in adult rat TMJ, focusing on their possible participation in the synovial vasculature. The desmin-positive B cell resembles an activated pericyte during angiogenesis in both immunoreactivities and ultrastructure. They existed adjacent to the capillaries and RECA-1 (endothelial marker)-positive A cells. Lectin-perfusion represented the functional vessels in synovial membrane. Some capillaries with RECA-1-reaction lacked lectin-staining, indicating a loss of blood-circulation due to vessel sprouting. RECA-1 and desmin-positive SLC often attached to this portion. A few capillaries also expressed ninein (sprouting tip cell marker). These findings suggest that SLC might contribute to angiogenesis in the synovial membrane.
|
| Free Research Field |
口腔解剖学
|
