Infection control with SLPI via the inhibitory effect on the proteases of Porphyromonas gingivalis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592775
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Iwate Medical University
• Principal Investigator: KIMURA Shigenobu 岩手医科大学, 歯学部, 教授 (10177917)
• Co-Investigator(Kenkyū-buntansha): NEMOTO Yuko (OHARA Yuko) 長崎大学大学院, 医歯薬学総合研究科, 准教授 (10164667)
• Co-Investigator(Renkei-kenkyūsha): SASAKI Minoru 岩手医科大学, 歯学部, 准教授 (40187133) ; SHIMOYAMA Yu 岩手医科大学, 歯学部, 助教 (90453331) ; ISHIKAWA Taichi 岩手医科大学, 歯学部, 助教 (10569247)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: SLPI / 感染制御 / P. gingivalis / プロテアーゼ阻害作用

Outline of Final Research Achievements

The results indicated that secretory leukocyte protease inhibitor (SLPI) showed a marked inhibitory effect on gingipains (Rgp and Kgp), the major and crucial proteases of Porphyromonas gingivalis, especially at relatively higher pH (8.0 and 8.5). Thus, SLPI could down-regulate the P. gingivalis infection in the gingival crevice through the inhibitory effect on gingipains.

Free Research Field

医歯薬学