2014 Fiscal Year Final Research Report
Investigation of virulence of microorganisms in polymicrobial infection
| Project/Area Number |
24592778
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Morphological basic dentistry
|
|---|
| Research Institution | Tokyo Dental College |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
INAGAKI Satoru (20385165)
KOKUBU Eitoyo (70453785)
KIKUCHI Yuichiro (30410418)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | Polymicrobial infection / バイオフィルム / 歯周炎 / 共凝集 / オートインデューサー / クオラムセンシング / デンタルプラーク / Porphyromonas gingivalis |
|---|
| Outline of Final Research Achievements |
Periodontitis is a typical polymicrobial infection. To clarify contribution of the bacterial interaction for development of periodontitis, we investigated the effect of co-culture of periodontopathic bacteria on virulence of each microorganisms. In the tested microorganisms, F. nucleatum enhanced biofilm formation by P. micra, which is predominant microorganism in apical periodontitis. In the combination of P. gingivalis and F. nucleatum, which are highly prevalent in chronic periodontitis, P. gingivalis enhanced biofilm formation by F. nucleatum, and F. nucleatum enhanced invasion of epithelial cells by P. gingivalis. These results suggest that enhancement of virulence by combination of the specific periodontopathic bacteria involves development of periodontitis.
|
| Free Research Field |
口腔微生物学
|
