Study of autoimmune reaction induced by Epstein-Brr virus (EBV)-encoded small RNA (EBER)

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592783
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Nihon Pharmaceutical University (2013-2014); Tsurumi University (2012)
• Principal Investigator: INOUE HIROKO 日本薬科大学, 薬学部, 准教授 (50367306)
• Co-Investigator(Kenkyū-buntansha): SAITO Ichiro 鶴見大学, 歯学部, 教授 (60147634) ; MURAMATSU Takashi 東京歯科大学, 歯学部, 教授 (00276982) ; RYO Kofuchi 鶴見大学, 歯学部, 講師 (10298268)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: Epstein-Barr virus / シェーグレン症候群 / 自己抗体 / TLR

Outline of Final Research Achievements

Sjogren's syndrome (SS) is an organ-specific autoimmune disease caused by the progressive loss of exocrine glands and is associated with several autoimmune phenomena. Several reports have suggested that reactivation of Epstein-Barr virus (EBV) may be a cause of SS. In this study, we revealed that EBV noncoding RNA, EBER, induced various cytokine in human salivary gland epithelial cell lines. In C57/B6 mice, nuclear extract (NE) from EBV infected B cell line induced expression of autoantibody, anti-SSB/La. Moreover, in NZW/NZB F1 mice, recombinant EBER induced anti-SSB/La antibody more efficiently than poly(I:C), TLR ligand.

Free Research Field

医歯薬学