2014 Fiscal Year Final Research Report
Functional analysis of Osterix in immature odontoblasts for cell differentiation
| Project/Area Number |
24592785
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Hiroaki 松本歯科大学, 歯学部, 教授 (50227930)
HIRAGA Toru 松本歯科大学, 歯学部, 准教授 (70322170)
YUKITA Akira 静岡大学, 教育学部, 講師 (80401214)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | Osterix / 象牙芽細胞 |
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| Outline of Final Research Achievements |
Osterix was localized in odontoblasts just beginning dentin matrix secretion during the processes of dentin formation and regeneration. However, as dentin formation progressed, this immunoreactivity decreased in intensity. In addition, although osteoblasts that were differentiated from dental pulp cells maintained the reactivity of Osterix, this reactivity was not detected in mature odontoblasts originated from pulp cells. Therefore, these results suggest that temporary expression of Osterix in odontoblast-lineage cells might play important roles in odontoblast differentiation and regeneration.
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| Free Research Field |
医歯薬学
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