2014 Fiscal Year Final Research Report
Role of Monad-interacting complex on tumorigenesis
| Project/Area Number |
24592795
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Niigata University (2013-2014)
Osaka University (2012) |
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Principal Investigator |
SAEKI Makio 新潟大学, 医歯学系, 教授 (30273692)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | R2TP / Monad / mTOR / Tumorigenesis |
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| Outline of Final Research Achievements |
R2TP was originally identified in yeast Saccharomyces cerevisiae as Hsp90 interacting complex, and is composed of four different proteins: Rvb1, Rvb2, Tah1, and Pih1. This complex is well-conserved in eukaryotes, and is involved in many cellular processes such as snoRNP biogenesis, RNA polymerase assembly, PIKK signaling, and apoptosis. An increasing number of research related
to R2TP suggests a linkage of its function with tumorigenesis. We provide an overview of several recent studies on R2TP that are related to cell proliferation and carcinogenesis, and propose a possible role of R2TP in tumorigenesis through regulating snoRNA/snoRNP biogenesis.
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| Free Research Field |
歯科薬理学
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