2014 Fiscal Year Final Research Report
Salivary miRNA as new cell-to-cell communication molecules
| Project/Area Number |
24592800
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MIZUSAWA Noriko 徳島大学, ヘルスバイオサイエンス研究部, 助教 (80254746)
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| Co-Investigator(Kenkyū-buntansha) |
IWATA Takeo 徳島大学, ヘルスバイオサイエンス研究部, 助教 (10350399)
YOSHIMOTO Katsuhiko 徳島大学, ヘルスバイオサイエンス研究部, 教授 (90201863)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | microRNA |
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| Outline of Final Research Achievements |
microRNAs (miRNAs), function as important regulators of a wide range of cellular processes by modulating gene expression. The functions and relate pathway of miRNAs have been extensively studied, but additional roles in various cellular processes remain to be understood.
We investigated the biological importance of individual miRNA to target-mRNA interactions by comparing miRNA-mRNA expression profiles in two normal human salivary gland cell lines named NS-SV-AC (AC) and NS-SV-DC (DC). Our results supports a miRNA can regulate several transcripts and the target-mRNAs are often context specific.
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| Free Research Field |
分子生物学
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