Mechanism of the rupture of meningeal-glia limitans during chronic Periodontitis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592802
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Functional basic dentistry
• Research Institution: Kyushu University
• Principal Investigator: TAKE Hiro 九州大学, 歯学研究科(研究院), 准教授 (10420598)
• Co-Investigator(Kenkyū-buntansha): NAKANISHI Hiroshi 九州大学, 歯学研究院, 教授 (20155774)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 歯周病 / ミクログリア / 髄膜 / アルツハイマー病

Outline of Final Research Achievements

Recently, Periodontitis has been accepted as a risk factor of Alzheimer’s disease. In the current study, we investigate the possibility and the mechanism of our hypothesis, which「Periodontitis, as a long term of low-grade systemic inflammation, can induces a breakdown of meningeal-glial protective system in brain, result in neuroinflammation-related memory loss」. We found that Periodontists bacteria (Porphyromonas Gingivalis, PG) and it LPS (PGLPS) induced a TLR2 dependent inflammatory mediator production by meningeal cells to activate microglia, resulting in impairment of learning and memory in the middle-aged mice. Moreover, the amplifying of microglia response with aging is a risk factor for neuroinflammation in Aβ dependent manner in the brain of Alzheimer’s disease.

Free Research Field

神経免疫科学、加齢科学