Study on a novel mechanism of bone metabolism implicating the function of a signaling molecule, PRIP

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592804
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Functional basic dentistry
• Research Institution: Kyushu University
• Principal Investigator: MATSUDA Miho 九州大学, 歯学研究科(研究院), 助教 (40291520)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 骨代謝 / 骨形成 / BMP / 骨吸収 / M-CSF / PRIP

Outline of Final Research Achievements

This study revealed the following:(i) PRIP, an inositol 1,4,5-trisphosphate binding and signaling molecule, is positively involved in the regulation of a signaling molecule, Smad6 which inhibits BMP signaling through the binding to BMP receptors or the interference of Smad1/5 phosphorylation. (ii) PRIP functions as a regulator of osteoclast differentiation at early stage, probably through the regulation of the expression and/or activity of a serin/threonine phosphoatage, calcineurin.
It was indicated that the deficiency of these functions cause the increased bone mineral density and trabecular bone volume in PRIP knockout mice.

Free Research Field

医歯薬学