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2014 Fiscal Year Final Research Report

Visualization of Neural circuits controlling feeding behavior

Research Project

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Project/Area Number 24592818
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Functional basic dentistry
Research InstitutionNihon University

Principal Investigator

KONDO Masahiro  日本大学, 歯学部, 講師 (50312294)

Co-Investigator(Renkei-kenkyūsha) TAMURA Takuya  東京医科歯科大学, 難治疾患研究所, 助教 (80396647)
Project Period (FY) 2012-04-01 – 2015-03-31
Keywords神経回路 / 化学感覚
Outline of Final Research Achievements

To visualize central neurons responsible for taste perception, we made transgenic animals expressing thermo-sensitive TRP ion channel (dTRPA) in taste cells. Heat stimulation of the sweet- and bitter-cells induced different patterns of ERK phosphorylation in the subesophageal ganglion. In addition, we tried to identify the neurons controlling feeding behavior using enhancer trap lines expressing sodium channel in a subset of neurons in the brain. We found that excitability of subset of dopaminergic neurons modulates the feeding behavior.

Free Research Field

神経生物学

URL: 

Published: 2016-06-03  

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