Role of BDNF on the excitability of trigeminal ganglion neurons involved in inflammatory hyperalgesia

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592819
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Functional basic dentistry
• Research Institution: Azabu University (2014); The Nippon Dental University (2012-2013)
• Principal Investigator: TAKEDA Mamoru 麻布大学, その他部局等, 教授 (20227036)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 三叉神経節ニューロン / BDNF / パラクリン / 炎症 / パッチクランプ法 / 免疫組織化学 / 電気泳動的投与 / 細胞外記録

Outline of Final Research Achievements

Present study investigated that the functional significance of hyperalgesia to the brain-derived neurotrophic factor (BDNF) tyrosine linase B (trkB) signaling system in trigeminal ganglion (TRG) neurons projecting to the trigeminal subnuclei interpolaris/ caudalis (Vi/Vc) transition region following masseter muscle inflammation under in vivo and in vitro conditions. We found that BDNF enhances the excitability of small –diameter TRG neurons projecting onto the Vi/Vc following masseter muscle inflammation. Thus, these findings suggest that ganglionic BDNF-trk B signaling is therapeutic targets for the treatment for trigeminal inflammatory hyperalgesia

Free Research Field

医歯薬学