Comprehensive analysis of the relationship between the function of ABC transporters and bone metabolism; from the view point of osteoclast generation and function

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592822
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Functional basic dentistry
• Research Institution: Chubu University
• Principal Investigator: NAKAGAWA Hiroshi 中部大学, 応用生物学部, 講師 (40397039)
• Co-Investigator(Renkei-kenkyūsha): TAKAMI Masamichi 昭和大学, 歯学部, 教授 (80307058) ; NAKAMURA Hiroaki 松本歯科大学, 歯学部, 教授 (50227930) ; HAGIWARA Hiromi 桐蔭横浜大学, 医用工学部, 教授 (90189465) ; HAYASHI Nobuhiro 東京工業大学, 生命理工学研究科, 准教授 (80267955) ; BANDO Masashige 東京大学, 分子細胞生物学研究所, 助教 (90360627)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ABC輸送体 / 骨代謝 / 破骨細胞

Outline of Final Research Achievements

We have been studying about the relationship between physiology of osteoclasts and function of ABC transporters. Since our previous studies have found that mRNA expression levels of 28 ABC transporters were increased during osteoclastgenesis, we investigated the function of the transporters by using knockout mice in the present study. Interestingly, Abcb4 and Abcc5 were found to regulate bone homeostasis, which were sex-dependent. These results suggest that ABC transporter can regulate bone homeostasis.

Free Research Field

骨代謝学、ABC輸送体学