2014 Fiscal Year Final Research Report
Inhibition of SCC proliferation and metastases with targeting aquaporin
| Project/Area Number |
24592831
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKURA Masaya 大阪大学, 大学院歯学研究科, 准教授 (10281130)
WADA Koichiro 鳥取大学, 医学部, 教授 (90263467)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 扁平上皮癌 / アクアポリン / 脂肪酸結合たんぱく質 |
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| Outline of Final Research Achievements |
Expression of aquaporin 3, 5 in oral squamous cell carcinoma (SCC) was much higher, whereas it in normal epithelium was null, suggesting ectopic expression of aquaporins in oral SCC. Knock-down of aquaporins in oral SCC cell lines resulted in the inhibition of cell proliferation. Moreover, we detected fatty acid-binding protein (FABP) in SCC prolireration. FABPs were expressed highly in oral SCC ectopically. FABP has an important role in proliferation of SCC through the MAPK pathway.
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| Free Research Field |
口腔外科
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