Role of inflammation in the initiation and development of oral squamous cell carcinoma

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592841
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Tokyo Medical University
• Principal Investigator: MIZUGUCHI Junichiro 東京医科大学, 医学部, 教授 (20150188)
• Co-Investigator(Renkei-kenkyūsha): TAKADA Eiko 東京医科大学, 医学部, 講師 (50110903) ; SATOMI Takafumi 東京医科大学, 医学部, 准教授 (70276921) ; YANASE Noriko 東京医科大学, 医学部, 講師 (10210303) ; HATA Kikumi 東京医科大学, 医学部, 講師 (30287156) ; TOYOTA Hiroko 東京医科大学, 医学部, 助手 (80468660) ; FURUHATA Masae 東京医科大学, 医学部, 助手 (90468661) ; KATAHIRA Takashi 東京医科大学, 医学部, ポストドクター (20626642)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 扁平上皮癌 / 炎症 / 転移 / 癌幹細胞

Outline of Final Research Achievements

Metastasis of tumor cells into lung was increased in mice with bronchial inflammation compared with control mice, while the lung metastasis was severely reduced in IL-10-deficient mice with bronchial inflammation. The cellular and molecular mechanisms underlying these events involve inflammatory responses, antibody responses, and interaction of chemokine and chemokine receptors. Next, we enriched cancer stem cells (CSCs) from the squamous cell carcinoma cell lines using a sphere-forming assay and cell surface markers, and have demonstrated that Akt played a crucial role in the function and maintenance of CSCs. Furthermore, we demonstrated that tumor growth was prevented by preadministration of modified tumor antigen and cytokine. Thus, these findings might be important for understanding of regulation of tumor growth and metastasis.

Free Research Field

免疫学、腫瘍学