2014 Fiscal Year Final Research Report
Monitoring of periodontal pathogen and analysis of regulatory mechanism in periodontitis-induced atherosclerosis
| Project/Area Number |
24592845
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 歯周病 / 動脈硬化 / A. actinomyctemcomitans / GFP |
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| Outline of Final Research Achievements |
Recentrly, numerous studies have been demonstrated that the involvement between the progression of atherosclerosis and oral infection by periodontal pathogens. It has been reported that periodontal pathogen-induced atherosclerosis may be regulated by direct (endothelial cell may be infected by periodontal pathogen), and indirect (development of atheromatous plaque may be attributed to endotoxin from periodontal pathogens) mechanisms. In this study, to analyze the direct role of periodontal pathogen to progress of atherosclerosis, we produced green fluorescent protein-expressing Aggregatibacter actinomycetemcomitans, which is one of the major periodontal pathogen, under the control of luekotoxin promotor for minitoring of A. actinomycetemcomitans after oral infection.
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| Free Research Field |
免疫学
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