2014 Fiscal Year Final Research Report
Study for subsets of lymphocyte which take a role on the mechanism that mesenchymal stem cells derived from dental pulp reduce graft versus host disease
| Project/Area Number |
24592851
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Asahi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KONDOH Nobuo 朝日大学, 歯学部, 教授 (40202072)
KAWAKI Harumi 朝日大学, 歯学部, 講師 (70513670)
KAMIYA Masako 朝日大学, 歯学部, 助教 (80181907)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 移植片対宿主病 / 間葉系幹細胞 |
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| Outline of Final Research Achievements |
The mechanism for that mesenchymal stem cells (MSCs) reduce graft versus host disease (GVHD) was investigated on the allogenic mixed-lymphocyte reaction with MSC as in vitro model for GVHD. Regardless of genotypes and expressing or not of major histocompatibility complex (MHC), MSCs reduced produced interferon-γ on this in vitro model. While subsets of lymphocyte which take a role on the mechanism reducing GVHD were not identified. The obtained results have suggested important information for treatment of GVHD with MSC derived from dental pulp on human patients.
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| Free Research Field |
口腔生化学
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