Quantitative diagnostic criteria for oral cancer using Doppler ultrasonigraphy

2015 Fiscal Year Final Research Report

• Project/Area Number: 24592855
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Fukuoka Dental College
• Principal Investigator: Yuasa Kenji 福岡歯科大学, 歯学部, 教授 (40136510)
• Co-Investigator(Kenkyū-buntansha): Kagawa Toyohiro 福岡歯科大学, 口腔歯学部, 准教授 (00258592) ; Miwa Kunihiro 福岡歯科大学, 口腔歯学部, 講師 (10136509) ; Chikui Tomoko (Shiraishi Tomoko) 福岡歯科大学, 口腔歯学部, 助教 (80580472) ; Horio Chika (yamamoto Chika) 福岡歯科大学, 口腔歯学部, 医員 (20636584)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 超音波ドプラ法 / 舌癌 / 口腔癌 / 頸部リンパ節転移 / 悪性度

Outline of Final Research Achievements

The purpose of this study is to quantitatively evaluate the relationship of vascularity of tongue cancer on intraoral US images with pathological grade of malignancy and presence of cervical lymph node metastases. Eighteen patients with tongue cancer were enrolled in this study. Using Doppler US images of the invasion front of the cancers along the length of their tumor boundaries, three vascular indexes were analyzed, namely ratio of blood flow signal area within the cancer to whole tumor area (BAR), blood flow signal number ratio (BNR), and blood flow signal width ratio (BWR). The associations between these three indexes and occurrence of cervical lymph node metastasis and pathological grade of malignancy were assessed.
The BNR and BWR of patients with cervical lymph node metastasis were significantly higher than those of patients without nodal involvement. The BWR of patients with high grade malignancy were significantly higher than those of patients with low grade malignancy.

Free Research Field

画像診断学