Elucidation of the metal dynamics of dental metal allergy

2015 Fiscal Year Final Research Report

• Project/Area Number: 24592860
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Tohoku University
• Principal Investigator: Shigehito Higuchi 東北大学, 歯学研究科(研究院), 大学院非常勤講師 (10291262)
• Co-Investigator(Kenkyū-buntansha): OGASAWARA KOUETSU 東北大学, 加齢医学研究所, 教授 (30323603)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: アレルギー

Outline of Final Research Achievements

Metal allergy is categorized in the delayed allergy, because the symptoms are developed at least 24 hours after contact with the metal. Elution of metal ion is known to be essential for the development of metal allergy. Although the metal ion might be bound to protein, the molecular mechanism is unknown. Accordingly, the present study is to reveal the dynamics of metal ions that cause allergies of metal. To clarify the kinetics of metal ions, we examined to visualize the nickel ions. We were able to develop the visualization of nichel ion by fluorescent dye. This visualization was realized and cell analyzer such as a fluorescence microscope or flow cytometry will be available. We were able to analyze the nickel at the cellular level uptake quantitatively and visually.

Free Research Field

歯学