Study on induction of the totipotent embryo-stem cells from human bone marrow mesenchymal stem cells

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592867
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Okayama University
• Principal Investigator: IZAWA Shunji 岡山大学, 医歯(薬)学総合研究科, 助教 (20273998)
• Co-Investigator(Renkei-kenkyūsha): YOSHIYAMA Masahiro 岡山大学, 大学院医歯薬学総合研究科, 教授 (10201071)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 骨髄間葉系幹細胞 / 脂肪由来幹細胞 / 免疫賦活因子 / 環境因子 / 細胞の初期化 / ES細胞 / 組織再生

Outline of Final Research Achievements

Based on our past results that bone marrow mesenchymal stem cells keep potential totipotency and activate tissue-specific totipotency by stimulation of inflammatory cytokine, we planned the induction experiment of the totipotent / embryo-stem cells from bone marrow mesenchymal stem cells.
And as the results, it was suggested that the combination of TNF α and activin A factor is useful for the initialization of not only bone marrow mesenchymal stem cells but also adiose dirived stem cells. as for this fact, not only the regeneration of the tooth but also the whole body is enabled, and the significance is profound.

Free Research Field

歯科保存修復学