2014 Fiscal Year Final Research Report
Creating a signaling-transcription factor network map that induces smads of dental pulp cells
| Project/Area Number |
24592885
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 歯髄組織 / 硬組織形成能 / メカニカルストレス / レーザー照射 / smads / BMP |
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| Outline of Final Research Achievements |
The smads responsible for TGF-b superfamily of intracellular signaling, such as BMP it's regarded as a factor that controls the promotion and suppression of hard tissue forming ability of the dental pulp. Expression of specific type smad1,5,8, by expression of inhibitory smad6,7, it is found that you have control of the hard tissue forming ability. When mechanical stress by laser with a wavelength of 660 nm or 810 nm to irradiate on pulp cells, an increase in the smad1 660 nm, was observed strongly increased the 810 nm smad5. On the other hand, it is allowed to act the kallikrein to produce kinin to promote hard tissue formation Smad1, 5 was increased in a time-dependent manner. smad6 is there is no change recognized a certain gene expression.
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| Free Research Field |
歯内療法学
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