2014 Fiscal Year Final Research Report
Plastic changes in cortical activities and dysfunctional specificity following treatment of movement disorders in orofacial region
| Project/Area Number |
24592936
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 口下顎ジストニア / NIRS / 筋電図 / センソリートリック / ボトックス注射 / 精神心理テスト / 感覚運動皮質 |
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| Outline of Final Research Achievements |
Iinvestigated the modulatory effects of use of a sensory trick on dystonic abnormal muscles activities and related activation of primary sensorimotor cortex in patients with oromandibular dystonia. Abnormal oromandibular dystonic muscle activities and related primary sensorimotor cortex activities were decreased by placing candy in the mouth. Furthermore, injection of botulinum toxin into the area of oromandibular dystonia led to significantly decreased abnormal oromandibular dystonic muscle activities and related primary cortex activation, as well as improvements in non-motor symptoms such as pain awareness and depressive mood state. Our findings indicate that both sensory trick and botulinum toxin injection modulate cortical activities related to oromandibular dystonia. In addition, such an injection improves both motor and non-motor symptoms in affected patients.
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| Free Research Field |
顎口腔機能
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