• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2014 Fiscal Year Final Research Report

Effect of Nanosheet Surface Structure of Titanium Alloys on Cell Differentiation

Research Project

  • PDF
Project/Area Number 24592942
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Prosthetic dentistry
Research InstitutionOsaka Dental University

Principal Investigator

KUSUMOTO Tetsuji  大阪歯科大学, 歯学部, 講師 (70186394)

Co-Investigator(Kenkyū-buntansha) TAKEDA Shoji  大阪歯科大学, 歯学部, 名誉教授 (20067185)
TAGUCHI Yoichiro  大阪歯科大学, 歯学部, 准教授 (60434792)
KOMASA Satoshi  大阪歯科大学, 歯学部, 助教 (70632066)
Project Period (FY) 2012-04-01 – 2015-03-31
KeywordsTNS / インプラント / オッセオインテグレーション
Outline of Final Research Achievements

We fabricated titania nanosheet (TNS) structures on titanium surfaces by NaOH treatment to improve bone differentiation on titanium alloy implants. The cellular response to TNSs on Ti6Al4V alloy was investigated, and the ability of the modified surfaces to affect osteogenic differentiation of rat bone marrow cells and increase the success rate of titanium implants was evaluated. The nanoscale network structures formed by alkali etching markedly enhanced the functions of cell adhesion and osteogenesis-related gene expression of rat bone marrow cells. Other cell behaviors, such as proliferation, alkaline phosphatase activity, osteocalcin deposition and mineralization, were also markedly increased in TNS-modified Ti6Al4V. Our results suggest that titanium implants modified with nanostructures promote osteogenic differentiation, which may improve the biointegration of these implants into the alveolar bone.

Free Research Field

歯科補綴学

URL: 

Published: 2016-06-03  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi