Mechanism of mechanoreceptive nerve regeneration: development of novel artificial dental roots with a mechanosensor

2016 Fiscal Year Final Research Report

• Project/Area Number: 24592951
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Tohoku University
• Principal Investigator: Hayashi Haruhide 東北大学, 歯学研究科, 大学院非常勤講師 (90107293)
• Project Period (FY): 2012-04-01 – 2017-03-31
• Keywords: 機械受容神経 / インプラント / メカニカルストレス / 歯根膜細胞 / 骨芽細胞 / 神経栄養因子

Outline of Final Research Achievements

Dental implant (artificial dental root) is a substitute for lost teeth and plays an important role in improving patient quality of life. This study aimed to elucidate the mechanism of mechanoreceptive nerve regeneration and to develop new dental implants with mechanosensors. Cell-specific expression of neurotrophic factors and neurotransmitters was elevated by mechanical stress loading on periodontal ligament cells and osteoblasts. Furthermore, gene expression pattern analysis suggested that several signal transduction pathways were involved in the process. These results have potential applications for the production of artificial dental roots that have mechanosensors similar to natural roots, have normal biting sensations, and exhibit physiological functions to suppress traumatic occlusal force.

Free Research Field

口腔生理学