2014 Fiscal Year Final Research Report
| Project/Area Number |
24592954
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
HARADA Kiyoshi 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (30228639)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | デンタルインプラント / 微小電流刺激 / 骨形成因子 / 骨増生シート / ポリロタキサン |
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| Outline of Final Research Achievements |
I tried the application of the bioactive substances such as bone morphogenetic factors for the purpose of raising activation of the bone formation activity by the microcurrent stimulation and the bone formation activity in this study more. I started the in vivo experiment using the beagle from 2013, but shifted to in vitro in experiment system because the repair work of laboratory animal facilities began. I prepared the bone regenerating seat to have the subperiosteal bone formation activity that another development focused in this research theme from the beginning of 2014. After paying its attention to a macromolecule called polyrotaxane as matrix, and giving the sulfate group to this, and giving it to the MC3T3E1 cell which was bone forming cell line, it became clear to significantly raise the bone formation activity of the cell.
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| Free Research Field |
外科系歯学、口腔外科
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