Establishment of Peri-implantitis treatment using injection of advanced platelet rich plasma/cells complex and photodynamic therapy.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592961
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Kagoshima University
• Principal Investigator: MATSUYAMA TAKASHI 鹿児島大学, 医歯(薬)学総合研究科, 准教授 (40253900)
• Co-Investigator(Kenkyū-buntansha): YOSHIMOTO Takehiko 鹿児島大学, 医学部・歯学部附属病院, 助教 (60419653) ; MACHIGASHIRA Miho 鹿児島大学, 医学部・歯学部附属病院, 講師 (80253897)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: インプラント周囲炎 / 光殺菌法 / GDF-5 / 多血小板血漿 / 骨再生

Outline of Final Research Achievements

The purpose of the present study was to evaluate cell biocompatibility and decontamination effect using photodynamic therapy and GDF-5/platelet-rich plasma(PRP)/mandibular periosteal cells complex. Photodynamic therapy on contaminated titanium surfaces led to decontamination without alteration of characterization on them. GDF-5/PRP complex enhanced activity of alkaline　phosphatase(ALP) in periosteal cells derived from rat mandibular compared to PRP alone stimulation. Furthermore, GDF-5/PRP complex induced the calcification of these cells on 14 days. These results suggest that GDF-5/PRP complex after photodynamic therapy on the contaminated titanium has an effect to induce bone regeneration.

Free Research Field

歯周治療系歯学